In no particular order
Metroid Prime 3 (Wii)
Super Mario Galaxy (Wii)
Assassin's Creed (360)
Hotel Dusk (DS)
God Of War 2 (PS2)
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In no particular order
Metroid Prime 3 (Wii)
Super Mario Galaxy (Wii)
Assassin's Creed (360)
Hotel Dusk (DS)
God Of War 2 (PS2)
Halo 3
Blue Dragon
Smash Bros. Brawl
Mario Galaxy
Massive tie between Mass Effect, Bioshock, and Lost Planet.
1) Resident Evil 5 - knowing how long it took for RE4 to come out, this probably won't be out until 2008. Maybe 2009. Don't really care that much about the Umbrella Chronicles (seems a bit too Gun Survivor-ish to me), but I might give it a chance.
2) Metal Gear Solid 4: Guns of the Patriots - I'll probably end up getting a PS3 just for this game (even though I skipped on MPO and the PSP), even if I don't really want to. Then I'll probably buy Metal Gear Solid 4 Subsistangral: Sweet Alabama Liquid Snake Edition as well because I'm such a tool for the series.
Other than a few Nintendo DS releases (Phoenix Wright 2, Hotel Dusk), there isn't much I'm looking forward except maybe Devil May Cry 4 and Smash Bros. Melee (if I decide to get a Wii).