Originally Posted by Geo
I like the idea of the Lizard and Kraven the Hunter.
Doc Connors becomes the Lizard, Peter tries to help him but can't, and then Kraven the Hunter decides to hunt down what is perceived to be the most dangerous beast alive. Spider-man gets in his way, causing him to fail, and captures the Lizard himself. Kraven then decides to then hunt the Spider-man and discovers Peter's identity in the process. Maybe throw in Puma as an earlier prey of Kraven, to see him in action (Peter watches the hunt on commercially-sold DVDs of Kraven's exploits).
Also, the increased inclusion of Doc Conners allows Gwen Stacy to stay in the story, as she's also a student in the class. I'd keep Capt. Stacy alive until Spider-man 5, probably bringing back a pissed off and more experienced Venom. Gwen Stacy hates Spider-man afterwards until she discovers his secret identity in Spider-man 6, and either she lives or dies afterwards.
Not sure what to do with Mary Jane though, although I'd love for a final battle where she wasn't a screaming damsel in distress: that's three movies we've seen that, now. Actually, now that I think about it, she could purposefully infiltrate Kraven's show/hunt to find out information about the Lizard and Kraven for Peter. Maybe Kraven falls for her and learns he is duped when he sees MJ kissing Peter/Spider-man, only fueling his anger towards Spider-man.