Castlevania: Harmony of Despair
Various sites are reporting Siliconera's discovery of Konami's new trademark, Harmony of Despair. The obvious consensus is that its the title of a new Castlevania game, likely a sequel to 2002's Harmony of Dissonance. Once you get past that though, it is all speculation.
PSP seems to be the "in" platform for development in Japan, and Konami just sent Peace Walker there, so that trend may continue here. However, I am hoping the platform is hidden in the acronym, much like Dawn of Sorrow. That would make the 360 and PS3 the likely targets. Perhaps this is an XBLA/PSN HD 2D sequel? Fingers, toes, etc. crossed, even if it won't be the action game the series should never have abandoned.