I went from a Master System to a Turbografx. So I played many games that most people haven't. As far as TNL though, I can't think of any that no one else would have played. Some of my favorites that probably weren't the best games, but I learned to like were
http://www.youtube.com/watch?v=pERiXbkK_n4
I like how the guy shoots the horses in the ass. I used to do the same thing.
http://www.youtube.com/watch?v=VgJNaLo2uH4&feature=related
You could send the bird out and in certain areas the background would crack open revealing a warp. I spent hours and hours sending that bird over every inch of every level. I also liked the switching of characters to use their specific powers to advance through a level. Probably why I liked The Lost Vikings so much later on. I can't play this game anymore. The slippery and loose control is too obnoxious. Didn't bother me much back in the day though!
http://www.youtube.com/watch?v=DzOgCzCVRZU
I LOVED Spy Hunter (sucked a shit ton at playing, but still LOVED) in the arcade. So when I saw this game for my Master System, I had to have it! It took me a while to find a youtube video where the guy playing actually knew what he was doing. I'm pretty sure I beat this game, but it was tough going. I miss the days where I could devote 5 or 6 hours a day to a single game for days on end.
On the Turbo side, I always dug this WARNING! OBNOXIOUS COMMENTARY AHEAD. Couldn't find a clip of just gameplay. Sorry.
http://www.youtube.com/watch?v=xK_gdjNBc5M
I sure it's nigh unplayable these days, but again, I was a kid with nothing but time. I don't know why I liked this, I didn't particularly care for the cartoon. Maybe it was the shitty air surfing segments?
Next is
http://www.youtube.com/watch?v=WIcQQxzdGu4
Historically, I've never been one for puzzle games. Tetris, Columns, Klax, etc can all fuck off. I really liked this one though. Maybe because it gives you more breathing room to figure out what you want to do? I'm kinda dumb, so I need time to form a strategy.
Lastly is
http://www.youtube.com/watch?v=diMtgy_H-eU
Incredibly derivative and fairly difficult, this was a shooter that I loved because it reminded me of so many other shooters I loved but had the silly backgrounds and enemies to keep it interesting and somewhat unique. I don't think I ever beat it, but came close a few times. I've never been one to toss controllers around due to frustration, but this game more than any other had me close to that point.

