Following up my prior post...
Mass Effect 2 (PS3) - Going from 0 to Insanity is a bitch, but I'm getting that God damned Platinum, and I'm not playing through it two more times. So the path less (and frustratingly) traveled it is! It really makes you notice where the game doesn't let you save, like where you have to send the cure through the air vents to help get the Salarian doctor to join. That should really be three separate checkpoints, but it's only one, and you can't manually save in the middle. So there are roughly seven waves of enemies, all with armor on Insanity, in-between save opportunities. Ouch.

