Funny that there isn't a thread about this yet. Steam tells me you all play this! IT DOES NOT LIE.
For the uninformed, The Binding of Isaac is a roguelike, NES Zelda-dungeon, twin-stick shooter by Edmund McMillan of Team Meat fame. It's about trying to run from and kill the titular Isaac's mother.
Have a trailer. There are puppets.
This game is like a REALLY GOOD hunk of peppery, beef jerky: tough and satisfying with good replay value. My favorite part of the game is seeing which crazy powerups I get and how they all work with one another.
Also, there's an expansion coming out!
Am I the only one that's been rather obsessed with this game? *glares at TrialSword*

