What kind of job are you looking for? I did full-on layout for GameFan later in my life there, and don't know jack about spot color, color seperation, or anything like that. I mean, I understand the basics about them, but I never dealt with them myself.
As well, it really depends on where you work when it comes to stuff like that. In the later days of GF, sending the stuff to the printer meant burning all of the Quark files, images, and whatever else was needed onto a CD, and shipping it off to the printer. With more things going straight digital, I'm not sure that knowing the ins and outs of things like that is as necessary anymore. Sure, it certainly won't hurt you, but I also think it won't always help.
WARNING: This post may contain violent and disturbing images.
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